Patents & Intellectual Property

Our groundbreaking patents represent revolutionary advances in regenerative medicine, cancer therapy, and drug delivery systems

3 Major Patents

Covering breakthrough technologies in healthcare

US & Chinese Patents

International patent protection secured

Full Documentation

Complete patent documents available for download

Chinese Patent

Miniature Skin Structure and Its Preparation Method and Use Thereof

Patent Number: ZL201010188002.X

Inventor: Dr. Guo Aihua

Organization: International Institute of Great Health

Abstract

The invention relates to a miniature skin structure which is formed by in vitro integration of epidermic cells and dermal cells, a preparation method and use thereof in medical and cosmetic fields.

Description

The miniature skin structure can be simply prepared and easily popularized, and miniature skin can be implanted in a living body or an in vitro activated culture organ and taken as a cell bank for supplying healthy cells. The miniature skin structure can also be used for detecting safety and effectiveness of drugs or cosmetics or developing an in vitro disease model, and the structure can be taken as a three-dimensional cell stereomodel for researching interaction between the dermal cells and the epidermic cells under pathological and physiological environmental conditions.

Key Points

  • The only transplantable active organ containing stem cell generative layer synthesized in vitro within the international field of regenerative medicine
  • Revolutionary change in clinical repair mode of wound healing
  • Active repair mode with stem cells replaces passive repair mode of traditional wound products
  • Promotes wound healing and improves repair quality
Miniature Skin Structure and Its Preparation Method and Use Thereof Patent Document
US Patent

Anti-Cancer Amylase Technology

Patent Number: US Patent (Granted June 2022)

Inventor: International Institute of Great Health Research Team

Organization: International Institute of Great Health

Background

When human eggs are fertilized by sperm, early cell division produces blastocysts (pre-implantation embryos). During the attachment process between blastocysts and the uterine wall, trophoblasts exhibit invasive behavior similar to cancer cells. There are striking similarities between trophoblast cells and cancer cells in terms of cellular function, development, protection, and impact on the host.

Scientific Foundation

Scottish embryologist John Beard first observed trophoblast invasive activity in 1902. He observed that trophoblast invasiveness roughly declined when the fetal pancreas began to develop. He believed that because the fetus obtained nutrition from the mother, these fetal pancreatic enzymes should have functions other than digestion.

Key Findings

  • Ionic amylase induces apoptosis in cancer cells
  • Ionic amylase reduces PD-L1 expression in cancer cells, making it useful as cancer immunotherapy
  • Ionic amylase reduces c-Myc expression, inhibiting tumor cell growth
  • Ionic amylase reduces inflammation and inhibits tumor cell metastasis
  • Ionic amylase inhibits breast cancer tumor growth in mice
  • Ionic amylase precipitates in mouse pancreas after oral administration, making it useful as an anti-pancreatic cancer agent
Anti-Cancer Amylase Technology Patent Document
US Patent

Oral Insulin Delivery System

Patent Number: US Patent (Granted November 2022)

Inventor: International Institute of Great Health Research Team

Organization: International Institute of Great Health

Technology

We have developed a novel technology called 'Protein Surface Ion Modification Technology' (PSIM). Using this technology, after changing the ions on the protein surface, the protein can be absorbed through the gastrointestinal tract and utilized by the human body.

This technology is fundamentally different from currently used 'absorption enhancers', 'liposomes' or 'nanoparticles'. Proteins processed through our technology can achieve absorption rates as high as 70%.

Applications

We have successfully converted 10 proteins into orally absorbable proteins, including Amylase, Trypsin, Lipase, 4H-3, MPHD3, 10H, GLP-1, ALA, Adipotide, and Insulin.

Oral Insulin Delivery System Patent Document